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KDX1381

CAT: 0931-T210637-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210637-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2757728-47-3
Target
Casein Kinase
Related Pathways
Stem Cells, Metabolism
Bioactivity
KDX1381 is a bivalent CK2α inhibitor with an IC50 of 17 nM and a KD of 54 nM. It demonstrates antitumor activity in murine 786-O and A375 xenograft models. Furthermore, when combined with a vascular endothelial growth factor receptor (VEGFR) inhibitor or DNA-damaging agents, KDX1381 enhances antitumor effects in mouse hepatocellular carcinoma and glioma models.
Smiles
O=C(C=1NC=2C=CC(F)=CC2C1C=3N=NN(C3)CC4CCN(CCNS(=O)(=O)C=5C=CC(=CC5)C=6C(F)=CC=CC6O)CC4)C
Molecular Formula
C32H32F2N6O4S
Molecular Weight
634.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19263153-01KDX1381

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