7,4'-Dimethoxy-3-hydroxyflavone

• Target:

  PKC|||Protease-activated Receptor|||ROS|||NF-?B|||Akt|||p38 MAPK|||Calcium Channel|||ERK

• Related Pathways:

  Chromatin/Epigenetic|||NF-?B|||Immunology/Inflammation|||Membrane transporter/Ion channel|||GPCR/G Protein|||Cytoskeletal Signaling|||MAPK|||Metabolism|||PI3K/Akt/mTOR signaling

• Bioactivity:

  7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. This compound inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 ?M. It disrupts PAR4-mediated aggregation and related signaling pathways, including NF-?B, Ca2+/protein kinase C (PKC), Akt, ERK, and p38. In a streptozotocin (STZ) -induced diabetic mouse model, 7,4'-Dimethoxy-3-hydroxyflavone inhibits vascular PAR4 expression, improves endothelial dysfunction, and reduces oxidative stress. Additionally, it prevents thrombosis in mice without affecting bleeding time.

• Smiles:

  O=C1C (O) =C (OC2=CC (OC) =CC=C21) C=3C=CC (OC) =CC3

• Molecular Formula:

  C17H14O5

• Molecular Weight:

  298.29

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  13198-99-7