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Halofenate

CAT: 0931-T210319-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0931-T210319-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
26718-25-2
Target
PPAR, Wnt/beta-catenin
Related Pathways
DNA Damage/DNA Repair, Cytoskeletal Signaling, Stem Cells, Metabolism
Bioactivity
Halofenate is an inhibitor for hypertriglyceridemia, effectively lowering serum triglyceride levels while having minimal impact on serum cholesterol. Additionally, it reduces serum uric acid and promotes uric acid excretion independent of glomerular filtration rate. Halofenate is associated with a significant increase in plasma thyroxine (T4), along with reductions in protein-bound iodine and T4. It can displace T4 from thyroid-binding proteins, which may influence thyroid function in the body.
Smiles
O=C(OCCNC(=O)C)C(OC1=CC=CC(=C1)C(F)(F)F)C2=CC=C(Cl)C=C2
Molecular Formula
C19H17ClF3NO4
Molecular Weight
415.79
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Halofenate

Halofenate is a selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) modulator with antilipidemic activity. Halofenate also decreases fasting plasma glucose in type 2 diabetic patients, but not normoglycemic subjects.

CAS Number26718-25-2
PubChem CID33584
IUPAC Name2-acetamidoethyl 2-(4-chlorophenyl)-2-[3-(trifluoromethyl)phenoxy]acetate
Molecular FormulaC19H17ClF3NO4
Molecular Weight415.8
XLogP4.3
Topological Polar Surface Area64.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count28
Formal Charge0
Complexity524
SMILES
CC(=O)NCCOC(=O)C(C1=CC=C(C=C1)Cl)OC2=CC=CC(=C2)C(F)(F)F
InChI
InChI=1S/C19H17ClF3NO4/c1-12(25)24-9-10-27-18(26)17(13-5-7-15(20)8-6-13)28-16-4-2-3-14(11-16)19(21,22)23/h2-8,11,17H,9-10H2,1H3,(H,24,25)
InChIKey
BJBCSGQLZQGGIQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Halofenate
CAS: 26718-25-2
CID: 33584
Formula: C19H17ClF3NO4
MW: 415.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight415.8
XLogP34.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass415.0798202
Monoisotopic Mass415.0798202
Topological Polar Surface Area64.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity524
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19262883-01Halofenate

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