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Trivalent hydroxyarsinothricn

CAT: 0931-T210094-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210094-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Glutaminase
Related Pathways
Proteases/Proteasome
Bioactivity
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA) . It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.
Molecular Formula
C4H10AsNO4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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