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Naphthol AS-MX phosphate

CAT: 0931-T209921-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209921-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1596-56-1
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
Naphthol AS-MX phosphate (NASTRp) is a small-molecule inhibitor targeting the CREB (cyclic adenosine monophosphate response element-binding protein) -CBP (CREB-binding protein) transcription factor complex. It exhibits antitumor activity against lung cancer cells by inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchorage-independent growth in soft agar. This compound is valuable for studying KRAS-mutant lung cancer, particularly in cases of chemotherapy resistance and poor prognosis.
Smiles
O=C(NC1=CC=C(C=C1C)C)C2=CC=3C=CC=CC3C=C2OP(=O)(O)O
Molecular Formula
C19H18NO5P
Molecular Weight
371.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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