TYM-3-98

CAT: 0931-T209787-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T209787-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2820244-59-3

Target

PI3K, Apoptosis

Related Pathways

Apoptosis, PI3K/Akt/mTOR signaling

Bioactivity

TYM-3-98 is a selective inhibitor of PI3Kδ with an IC50 of 7.1 nM. It inhibits the proliferation of B lymphoma cells by inducing apoptosis and suppressing the PI3K/AKT/mTOR signaling pathway. In mouse/rat models, TYM-3-98 displays favorable pharmacokinetic properties and antitumor activity without significant toxicity.

Smiles

O=S(=O)(C=1C=CC=C(C1)N2N=C(C=3C=CC(Cl)=CC32)C(N4N=C(C=5C=CC(OC)=C(F)C5)C=6C(=NC=NC64)N)C)C

Molecular Formula

C28H23ClFN7O3S

Molecular Weight

592.05

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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TYM-3-98

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