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JN122

CAT: 0931-T208846-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T208846-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
MDM-2/p53, Apoptosis
Related Pathways
Apoptosis
Bioactivity
JN122 is a spiroindoline-containing molecule that acts as an MDM2 inhibitor. It disrupts the MDM2/p53 protein-protein interaction, exhibiting potent antitumor effects in vivo. JN122 demonstrates antiproliferative activity, with IC50 values of 39.6 nM in HCT-116 cells and 4.28 μM in HEK-293 cells. It induces the activation of p53 and its target genes, halts cell cycle progression, and triggers apoptosis.
Molecular Formula
C33H37Cl2N3O4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-163083JN122

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