Steffimycin B

• CAS Number :

  54526-94-2

• Target :

  Antibacterial

• Related Pathways :

  Microbiology/Virology

• Bioactivity :

  Steffimycin B is an anthracycline bacterial metabolite initially isolated from Streptomyces. It binds to DNA, preferentially intercalating at sites containing cytosine and guanine. Steffimycin B exhibits cytotoxicity against MCF-7, KB, NCI-H187, and Vero cells with IC50 values of 3.5, 6.75, 3.28, and 10.5 ?M, respectively. It also shows activity against *Mycobacterium tuberculosis* (MIC=5.2 nM), *Bacillus cereus* (MIC=1.56 ?g/mL), and *Plasmodium falciparum* (IC50=2.19 ?M) .

• Smiles :

  O([C@@H]1C2=C(C=C3C(=C2O)C(=O)C=4C(C3=O)=CC(OC)=CC4O)C(=O)[C@@](C)(O)[C@H]1OC)[C@H]5[C@H](OC)[C@H](O)[C@@H](OC)[C@H](C)O5

• Molecular Formula :

  C29H32O13

• Molecular Weight :

  588.56

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C