CDK7-IN-26

• Target :

  CDK

• Related Pathways :

  Cell Cycle/Checkpoint

• Bioactivity :

  CDK7-IN-26 (compound 36) is an orally active CDK7 inhibitor with an IC50 of 7.4 nM. The compound effectively suppresses the growth of xenograft tumors derived from triple-negative breast cancer (TNBC) cell lines in vivo and has an IC50 of 0.15 ?M for inhibiting MDA-MB-453 cells in vitro.

• Smiles :

  N(C1=NC(=C2C(=N1)C=CS2)C=3C=4C(NC3)=C(P(C)(C)=O)C(C#N)=CC4)[C@H]5C[C@H](F)CNC5

• Molecular Formula :

  C22H22FN6OPS

• Molecular Weight :

  468.49

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3024545-79-4