Vancomycin prodrug

CAT: 0931-T207721-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T207721-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Autophagy|||Antibiotic|||Antibacterial
Related Pathways
Autophagy|||Microbiology/Virology
Bioactivity
Vancomycin prodrug (compound 13c) is a prodrug of Vancomycin. It exhibits antibacterial activity against Staphylococcus aureus (S. aureus) 330041, methicillin-resistant Staphylococcus aureus (MRSA) USA 300, and MRSA 3390, with minimum inhibitory concentrations (MICs) of 0.78 ?M, 0.78 ?M, and 1.56 ?M, respectively. This prodrug can rapidly bind to the Cys-34 residue in plasma. It demonstrates therapeutic efficacy in mice infected with MRSA USA300, comparable to Vancomycin. As an albumin-binding, acid-sensitive prodrug, Vancomycin prodrug maintains Vancomycin's effectiveness against gram-positive bacterial infections while significantly reducing nephrotoxicity.
Molecular Formula
C85H95Cl2N11O29
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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