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FGA139

CAT: 0931-T207702-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207702-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Cysteine Protease, NO Synthase, TNF
Related Pathways
Immunology/Inflammation, Proteases/Proteasome, Apoptosis
Bioactivity
FGA139 is an inhibitor of cysteine proteases, specifically targeting cathepsin B and L with IC50 values of 4.98 μM and 3.14 μM, respectively. It reduces the production of NO in LPS-induced RAW264.7 cells and lowers TNFα levels in microglia, demonstrating antioxidant and anti-inflammatory properties. Additionally, FGA139 enhances the secretion of neuroprotective metabolites such as purines and linoleic acid in LPS-stimulated microglia. This compound is applicable in the study of neuroinflammatory diseases.
Molecular Formula
C48H58BF2N7O5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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