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Ferumoxytol

CAT: 0931-T207484-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207484-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
722492-56-0
Target
Ferroptosis, Reactive Oxygen Species
Related Pathways
Immunology/Inflammation, NF-κB, Metabolism, Apoptosis
Bioactivity
Ferumoxytol is an iron oxide nanoparticle with anti-leukemia properties, specifically against acute myeloid leukemia (AML) cells with low ferroportin (FPN) expression. By increasing intracellular iron levels, Ferumoxytol induces the Fenton reaction to produce reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis. It selectively kills leukemia cells with low FPN expression while sparing normal cells, making it useful for studying leukemia targeting iron metabolism abnormalities.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19257728-01Ferumoxytol

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