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JV8

CAT: 0931-T207301-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207301-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2841716-61-6
Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
JV8 is a BRD4 PROTAC degrader that facilitates ubiquitination and degradation of BRD4, inducing apoptosis (Apoptosis) . It exhibits antitumor activity in a mouse 4T1 orthotopic tumor model.
Smiles
CC=1C2=C(N3C([C@H](CC(NCCOCCOCCOCC(N[C@@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@@](C)(C)C)=O)=O)N=C2C7=CC=C(Cl)C=C7)=NN=C3C)SC1C
Molecular Formula
C50H62ClN9O8S2
Molecular Weight
1016.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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