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YX0798

CAT: 0931-T207141-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207141-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, c-Myc, Bcl-2 Family, CDK
Related Pathways
Apoptosis, Cell Cycle/Checkpoint
Bioactivity
YX0798 is a selective, orally active CDK9 inhibitor (Kd: 0.28 nM) . It downregulates the oncogenic protein c-MYC and the pro-survival protein MCL-1. YX0798 disrupts the cell cycle and causes transcriptome reprogramming, ultimately leading to apoptosis. The compound exhibits antitumor activity.
Smiles
ClC(C=NC(NC([C@H]1CCC[C@@H](NC(C(F)(F)F)=O)C1)=O)=C2)=C2C3=C4C(NC=C4)=NC=C3
Molecular Formula
C21H19ClF3N5O2
Molecular Weight
465.86
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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