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(S) -dHTC1

CAT: 0931-T206969-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206969-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3081383-46-9
Target
PROTACs
Related Pathways
PROTAC
Bioactivity
(S) -dHTC1 is a molecular glue degrader specifically targeting the transcriptional coactivator ENL. It exhibits high affinity binding to E3 ligase only upon formation of the ENL: (S) -dHTC1 complex, with an IC50 of 93 nM. In MV4;11 cells, (S) -dHTC1 degrades ENL with a DC50 of 26 nM. This compound can be utilized for acute myeloid leukemia research.
Smiles
O=C1[C@]2(CN(S(NC3CCN(CCNC(=O)C4=CC(=CC=C4)C5=CN6C(=N5)C=CC(C(NC7CCC7)=O)=C6)CC3)(=O)=O)CC2)CC(=O)N1
Molecular Formula
C33H40N8O6S
Molecular Weight
676.786
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
HY-173631(S) -dHTC1

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