TCL1

• Target :

  Proteasome

• Related Pathways :

  Proteases/Proteasome|||Ubiquitination

• Bioactivity :

  TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 ?M. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.

• Smiles :

  O=C(O)CC1SC2=NN=C(N2N=C1C=3C=CC(Cl)=CC3)CC4=CC=C(Br)C=C4

• Molecular Formula :

  C19H14BrClN4O2S

• Molecular Weight :

  477.762

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  875165-39-2