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TCL1

CAT: 0931-T206909-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206909-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
875165-39-2
Target
Proteasome
Related Pathways
Proteases/Proteasome, Ubiquitination
Bioactivity
TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
Smiles
O=C(O)CC1SC2=NN=C(N2N=C1C=3C=CC(Cl)=CC3)CC4=CC=C(Br)C=C4
Molecular Formula
C19H14BrClN4O2S
Molecular Weight
477.762
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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