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Clifutinib

CAT: 0931-T206767-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206767-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1862226-99-0
Target
PI3K, Akt, p38 MAPK, Apoptosis, FLT, Ras, STAT, JAK
Related Pathways
Angiogenesis, Chromatin/Epigenetic, JAK/STAT signaling, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, MAPK, Cytoskeletal Signaling, GPCR/G Protein, Apoptosis, Stem Cells
Bioactivity
Clifutinib (Compound 9e) is an orally active, selective inhibitor of FMS-like tyrosine kinase 3 (FLT3-ITD) with an IC50 of 15.1 nM. It inhibits FLT3-ITD kinase activity and blocks downstream signaling pathways, including RAS/MAPK, PI3K/AKT, and JAK/STAT5. Clifutinib induces apoptosis in FLT3-ITD mutated acute myeloid leukemia (AML) cells and is a potential candidate for research in relapsed/refractory FLT3-ITD positive AML.
Smiles
O=C(NC1=NOC(=C1)C(C)(C)C)NC2=CC=C(C#CC3=CC=C(OCCCN4CCOCC4)C=C3)C=C2
Molecular Formula
C29H34N4O4
Molecular Weight
502.605
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19258313-01Clifutinib

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