Products for Research Use Only

TEC 4

CAT: 0931-T206644-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206644-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Epigenetic Reader Domain
Related Pathways
Chromatin/Epigenetic
Bioactivity
TEC 4 is a ByeTAC (bypass E3 ligase targeting chimera) that acts as a BRD4 degrader. At a concentration of 500 nM, it results in 33% residual BRD4 in Ramos B cells. Additionally, TEC 4 exhibits toxicity in Ramos B cells with an IC50 of 30.5 nM. ByeTAC recruits proteins directly to the proteasome for degradation by interacting with Rpn-13.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C