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GHN105

CAT: 0931-T205672-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205672-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Interleukin, STING, IFNAR
Related Pathways
Immunology/Inflammation
Bioactivity
GHN105 is an orally active STING inhibitor that suppresses STING-dependent IFN-β secretion in THP-1 human monocytes with an IC50 of 4.4 μM. In mice, GHN105 reduces serum levels of IFN-β, IL-6, and CXCL10, and alleviates colitis in a DSS-induced acute colitis mouse model. Additionally, GHN105 demonstrates favorable pharmacokinetic properties in mice, with an oral bioavailability of 43% and a half-life of 1.1 hours.
Molecular Formula
C41H56N2O14
Molecular Weight
800.89
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19249109-01GHN105

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