AA-BR-157

• Target :

  PROTACs

• Related Pathways :

  PROTAC

• Bioactivity :

  AA-BR-157 is a PROTAC degrader targeting metallothionein 2A (MT2A) with a DC50 of 190 nM. It downregulates DIAPH3, a protein involved in cytoskeletal and cellular movement regulation, inhibiting cell migration in MDA-MB-231 and U-87 MG cell lines. Additionally, AA-BR-157 modulates zinc homeostasis in MDA-MB-231 cells. (Pink: ligand for target protein MT2A ligand 1; Black: linker; Blue: ligand for VHL E3 ligase) .

• Molecular Formula :

  C56H70N8O11S2

• Molecular Weight :

  1095.33

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C