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DSM1465

CAT: 0931-T205563-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205563-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Dehydrogenase, Parasite
Related Pathways
Microbiology/Virology, Metabolism
Bioactivity
DSM1465 (Compound 82) is a potent and selective inhibitor of P. falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC50 value of 15 nM. It inhibits P. falciparum 3D7 (Pf3D7) parasites with an EC50 value of 1.4 nM and demonstrates significant in vivo efficacy in humanized P. falciparum mouse models.
Smiles
ClC1=C(C(F)(F)F)N=CC([C@](C2=C3C(C(N(C4CC4)C=N3)=O)=NN2C)(O)C(F)(F)F)=C1
Molecular Formula
C17H12ClF6N5O2
Molecular Weight
467.753
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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