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GL392

CAT: 0931-T205507-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205507-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis
Related Pathways
Apoptosis
Bioactivity
GL392 is a senolytic agent that delivers the potent senescence-clearing compound Dasatinib specifically to senescent cells. By targeting the LBD domain, it binds lipofuscin in these cells and releases Dasatinib via an ester linkage, inducing apoptosis (Apoptosis) in senescent cells. Additionally, GL392 is encapsulated in PEO-b-PCL microcapsules to ensure efficient intracellular delivery while minimizing systemic toxicity. GL392 is applicable in cancer research.
Smiles
O=C(CCC(OCCN1CCN(C2=CC(NC3=NC=C(C(NC4=C(C=CC=C4Cl)C)=O)S3)=NC(C)=N2)CC1)=O)OCC(N5)(C)NC6=CC=CC(C6=C5C=C7)=C7/N=N/C(C=C8)=C9C(C=CC=C9)=C8/N=N/C%10=CC=CC=C%10
Molecular Formula
C55H52ClN13O5S
Molecular Weight
1042.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19249272-01GL392

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