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BW710

CAT: 0931-T205382-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205382-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
FGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
BW710 is an orally active inhibitor specifically targeting fibroblast growth factor receptor 2 (FGFR2) . It effectively inhibits the proliferation of BaF3-FGFR2 cells with an IC50 value of 2.8 nM. BW710 completely suppresses FGFR2 enzymatic activity and demonstrates selectivity among 75 tyrosine kinases, including FGFR1, FGFR3, and FGFR4, at a 1 μM concentration. Additionally, BW710 impedes FGFR2 signaling and selectively inhibits the proliferation of cancer cells driven by FGFR2. It exhibits promising pharmacokinetic properties, with an oral bioavailability of 29% in mice.
Molecular Formula
C28H29FN6O2S
Molecular Weight
532.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-170934BW710

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