LYG-409

• Target :

  Molecular Glues

• Related Pathways :

  PROTAC

• Bioactivity :

  LYG-409 is an orally active GSPT1 degrader. It demonstrates exceptional in vivo anti-tumor activity against acute myeloid leukemia and prostate cancer, with tumor growth inhibition rates (TGI) of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells by degrading GSPT1, with an IC50 of 9.50 nM and a DC50 of 7.87 nM in vitro.

• Smiles :

  O=C(NCC1=CC=C2C(=O)N(CC2=C1)C3C(=O)NC(=O)CC3)C4=CC=5C=C(OC(F)(F)F)C=CC5OC4

• Molecular Formula :

  C25H20F3N3O6

• Molecular Weight :

  515.438

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3053857-55-6