LYG-409

CAT: 0931-T205349-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T205349-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3053857-55-6
Target
Molecular Glues
Related Pathways
PROTAC
Bioactivity
LYG-409 is an orally active GSPT1 degrader. It demonstrates exceptional in vivo anti-tumor activity against acute myeloid leukemia and prostate cancer, with tumor growth inhibition rates (TGI) of 94.34% and 104.49%, respectively. LYG-409 inhibits KG-1 cells by degrading GSPT1, with an IC50 of 9.50 nM and a DC50 of 7.87 nM in vitro.
Smiles
O=C(NCC1=CC=C2C(=O)N(CC2=C1)C3C(=O)NC(=O)CC3)C4=CC=5C=C(OC(F)(F)F)C=CC5OC4
Molecular Formula
C25H20F3N3O6
Molecular Weight
515.438
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

CatalogName
C03615-01LYG-409
A24461-10LYG-409 10mg
A24461-5LYG-409 5mg
A24461-50LYG-409 50mg
A24461-100LYG-409 100mg
sc-396595LYG-202
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HY-158113-01CBPD-409
HY-110057-01FR 409
HY-19090FK 409

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