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MU147

CAT: 0931-T205293-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205293-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2379405-61-3
Target
Endonuclease
Related Pathways
Cell Cycle/Checkpoint
Bioactivity
MU147 is an MRE11 nuclease inhibitor and chemical probe with anticancer properties, exhibiting lethal effects on Ehrlich ascites tumor cells both in vivo and in vitro. It disrupts the MRE11 nuclease-dependent double-strand break repair mechanism without impairing ATM activation. Additionally, MU147 damages the degradation of nascent strands at stalled replication forks and selectively affects BRCA2-deficient cells.
Smiles
N(C(/C(=C/C1=CC(O)=C(O)C=C1)/C#N)=O)C2=NC(=CS2)C3=CC=CC=C3
Molecular Formula
C19H13N3O3S
Molecular Weight
363.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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