KKL-40

• Target :

  Antibacterial|||Antibiotic

• Related Pathways :

  Microbiology/Virology

• Bioactivity :

  KKL-40 is a small-molecule inhibitor that targets the trans-translation process, effectively suppressing methicillin-sensitive and resistant Staphylococcus aureus (S. aureus) and other Gram-positive pathogens, including vancomycin-resistant Enterococcus faecium, Bacillus subtilis, and Streptococcus pyogenes. It works in synergy with the human antimicrobial peptide LL-37 to inhibit S. aureus, but does not show synergistic effects with other antibiotics such as daptomycin, kanamycin, or erythromycin. KKL-40 inhibits trans-translation, an extreme form of recoding, while being non-toxic to HeLa cells.

• Smiles :

  O=C(NC1=NN=C(O1)C=2C=CC(F)=CC2)C3=CC=CC(=C3)C(F)(F)F

• Molecular Formula :

  C16H9F4N3O2

• Molecular Weight :

  351.255

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  865285-47-8