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DA-0157

CAT: 0931-T205118-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T205118-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2756978-82-0
Target
ALK|||Cytochromes P450|||EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Metabolism|||JAK/STAT signaling|||Angiogenesis
Bioactivity
DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC) . It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 ?M), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM) . Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 ?M and demonstrates antitumor activity in mouse models.
Smiles
O=P(C1=CC(=CC=C1NC2=NC(=NC=C2Br)NC=3C=C(C(=CC3OC)N4CCC(N5CCN(C)CC5)CC4)C)C)(C)C
Molecular Formula
C31H43BrN7O2P
Molecular Weight
656.597
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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