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ARN23765

CAT: 0931-T205032-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205032-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2244458-40-8
Target
CFTR
Related Pathways
Membrane transporter/Ion channel
Bioactivity
ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF) .
Smiles
O([C@@H]1C=2N(N=C(C(F)(F)F)C2CCC1)C3=CC(C(N(C)C=4C=C5C(=CC4)OC(F)(F)O5)=O)=CC=C3)C6=CC=C(C(O)=O)C=C6
Molecular Formula
C30H22F5N3O6
Molecular Weight
615.504
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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