XY221

CAT: 0931-T204924-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T204924-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Apoptosis, c-Myc, Epigenetic Reader Domain, Bcl-2 Family, AMPK, PAK

Related Pathways

PI3K/Akt/mTOR signaling, Apoptosis, Cell Cycle/Checkpoint, Chromatin/Epigenetic, Cytoskeletal Signaling

Bioactivity

XY221 (Compound 16o) selectively inhibits BRD4 BD2 with an IC50 of 5.8 nM. It demonstrates high selectivity for pan-BD2 and BRD4 BD2 domains, being 667 times more selective than for BRD4 BD1, and 9-32 times more selective than for BRD2/3/T BD2. XY221 can induce apoptosis in MV4-11 cells and exhibits anti-cancer activity.

Smiles

CCC1=NC(=C(N1)COC)C2=CC3=C(O2)C(=CN(C3=O)C)C4=C(C=CC(=C4)C(C)(C)O)OC5=C(C=C(C=C5C)F)C

Molecular Formula

C32H34FN3O5

Molecular Weight

559.628

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
GTR19249729-01	XY221

XY221

Alternative Products

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