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FW-1

CAT: 0931-T204464-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204464-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, FLT
Related Pathways
Apoptosis, Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
FW-1 is a type I inhibitor of FLT3, with an IC50 of approximately 1 μM. It exhibits cytotoxic effects in FLT3-mutant AML cells, causes cell cycle arrest at the G0/G1 phase, and induces apoptosis in MV4-11 and MOLM-13 cells.
Smiles
CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC4=C(C(=C3)NC5=CC=CC=C5)C(=NO4)N
Molecular Formula
C24H27N7O
Molecular Weight
429.517
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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