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PB01

CAT: 0931-T204296-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204296-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
368434-78-0
Target
Reactive Oxygen Species, Proteasome
Related Pathways
Immunology/Inflammation, Metabolism, NF-κB, Ubiquitination, Proteases/Proteasome
Bioactivity
PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.
Smiles
O=C1C2=C(N=C(N2CC=3C=CC=CC3)N4CCOCC4)N(C(=O)N1C)C
Molecular Formula
C18H21N5O3
Molecular Weight
355.391
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19250370-01PB01

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