Purinostat

• CAS Number :

  1929583-17-4

• Target :

  HDAC

• Related Pathways :

  DNA Damage/DNA Repair|||Chromatin/Epigenetic

• Bioactivity :

  Purinostat is a selective inhibitor of HDACI/IIb with potential anti-leukemic properties. Its mesylate form, Purinostat mesylate, is effective at inhibiting the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDACI/IIb, impacting several crucial factors for leukemia stem cell (LSC) survival, such as c-Myc, ?-Catenin, E2f, Ezh2, Alox5, and mTOR. Additionally, Purinostat mesylate enhances glutamate metabolism in LSCs by increasing GLS1.

• Smiles :

  O=C(NO)C1=CN=C(N=C1)N(C)CC2=NC=3C(=NC(=NC3N4CCOCC4)C=5C=CC(N)=CC5)N2C

• Molecular Formula :

  C23H26N10O3

• Molecular Weight :

  490.518

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C