Trimethylcolchicinic acid

CAT: 0931-T204087-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T204087-01Size:1 mg

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CAS Number

3482-37-9

Target

Microtubule Associated

Related Pathways

Cytoskeletal Signaling

Purity

>99.99%

Bioactivity

Trimethylcolchicinic acid (N-Deacetylcolchiceine) is an orally available colchicine analog that binds to tubulin and inhibits its polymerization into microtubules, preventing cell division and having potential antitumor activity.

Smiles

O(C)C1=C2C=3C(=CC(=O)C(O)=CC3)[C@@H](N)CCC2=CC(OC)=C1OC

Molecular Formula

C19H21NO5

Molecular Weight

343.37

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Trimethylcolchicinic Acid

Trimethylcolchicinic Acid is a colchicine analog with potential antineoplastic activity. Trimethylcolchicinic acid binds to tubulin, inhibiting its polymerization into microtubules and preventing cell division. (NCI04)

CAS Number	3482-37-9
PubChem CID	453131
IUPAC Name	(7S)-7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one
Molecular Formula	C19H21NO5
Molecular Weight	343.4
XLogP	0.9
Topological Polar Surface Area	91
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Heavy Atom Count	25
Formal Charge	0
Complexity	623

SMILES

COC1=C(C(=C2C(=C1)CC[C@@H](C3=CC(=O)C(=CC=C32)O)N)OC)OC

InChI

InChI=1S/C19H21NO5/c1-23-16-8-10-4-6-13(20)12-9-15(22)14(21)7-5-11(12)17(10)19(25-3)18(16)24-2/h5,7-9,13H,4,6,20H2,1-3H3,(H,21,22)/t13-/m0/s1

InChIKey

IRVWPZRYDQROLU-ZDUSSCGKSA-N

Chemical Structure

2D Structure

CAS: 3482-37-9

CID: 453131

Formula: C19H21NO5

MW: 343.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	343.4
XLogP3	0.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	3
Exact Mass	343.14197277
Monoisotopic Mass	343.14197277
Topological Polar Surface Area	91 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	623
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
HY-105526	Trimethylcolchicinic acid
MBS6107106-01	N-Deacetylcolchiceine (Trimethylcolchicinic Acid)
OR1071368-01	Acid-apeg6-acid
MBS6083807-01	Medronic Acid (Methylenebiphosphonic Acid, Methylenediphosphonic Acid, Methanebisphosphonic Acid, Methanediphosphonic Acid, MDP)
L2500-01	Lipoic Acid (Thioctic Acid, (±) -α-Lipoic Acid)
041005	Cacodylic Acid (dimethylarsonic acid, dimethylarsinic acid)
O8099-01	Oxalacetic Acid (Oxaloacetic acid)
275335-01	Ethylenediaminediacetic acid dipropionic acid
MBS6036559-01	a-Lipoic Acid (Thioctic Acid)
MBS651473-01	Ambuic acid ((+)-Ambuic acid)

Trimethylcolchicinic acid

Chemical Information

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