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ZZ151

CAT: 0931-T203779-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203779-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Ras, PROTACs, Kras
Related Pathways
PROTAC, MAPK
Bioactivity
ZZ151 is an effective and selective SOS1 PROTAC with in vivo anti-tumor efficacy against KRAS-mutant cancers. This compound induces rapid and specific degradation of SOS1 and exhibits strong anti-proliferative activity against a wide range of KRAS mutation-driven cancer cells. In murine xenograft models with KRASG12D and G12V mutations, ZZ151 demonstrates superior anticancer activity. It represents a promising lead compound for developing new chemotherapeutic agents targeting KRAS mutations.
Smiles
O=C([C@H]1N(C([C@@H](NC(CCCCCC(N2CCC(C3=CC4=C(N[C@@H](C5=CC(C(F)(F)F)=CC(N)=C5)C)N=C(C)N=C4C=C3OC)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
Molecular Formula
C54H68F3N9O6S
Molecular Weight
1028.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19240869-01ZZ151

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