YT 6-2

• CAS Number :

  2409959-90-4

• Target :

  AUTACs

• Related Pathways :

  PROTAC

• Bioactivity :

  YT 6-2 is an autophagy-targeting ligand (ATL) aimed at p62/SQSTM1, used in the synthesis of AUTOTAC degrader ATC-324. ATC-324 induces the formation of AR/p62 complexes, leading to the autophagic-lysosomal degradation of AR. It reduces nuclear AR levels, downregulates the expression of AR and AR-v7 target genes, and also degrades common AR mutants in PCa.

• Smiles :

  O(CC1=CC=C(F)C=C1)C2=C(OCC3=CC=C(F)C=C3)C=CC(OC[C@@H](CNCCO)O)=C2

• Molecular Formula :

  C25H27F2NO5

• Molecular Weight :

  459.48

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C