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YT 6-2

CAT: 0931-T203019-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T203019-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2409959-90-4
Target
AUTACs
Related Pathways
PROTAC
Bioactivity
YT 6-2 is an autophagy-targeting ligand (ATL) aimed at p62/SQSTM1, used in the synthesis of AUTOTAC degrader ATC-324. ATC-324 induces the formation of AR/p62 complexes, leading to the autophagic-lysosomal degradation of AR. It reduces nuclear AR levels, downregulates the expression of AR and AR-v7 target genes, and also degrades common AR mutants in PCa.
Smiles
O(CC1=CC=C(F)C=C1)C2=C(OCC3=CC=C(F)C=C3)C=CC(OC[C@@H](CNCCO)O)=C2
Molecular Formula
C25H27F2NO5
Molecular Weight
459.48
Shipping Conditions
Ice Packs
Storage Temperature
-20°C