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YD-3

CAT: 0931-T202985-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T202985-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
170632-41-4
Target
Thrombin
Related Pathways
Proteases/Proteasome
Bioactivity
YD-3 is a PAR4 antagonist that significantly inhibits thrombin-induced platelet aggregation in rabbits (IC (50) =28.3 microM) . In addition, YD-3 suppresses thrombin-induced proliferation of vascular smooth muscle cells (VSMCs) and reduces neointimal thickening after balloon injury. Through Ras- and ERK1/2-mediated signaling pathways, YD-3 impedes thrombin-driven VSMC proliferation. When analyzed with Western blot, YD-3 primarily inhibits thrombin-induced expression of vascular endothelial growth factor receptor 2 (Flk-1) without affecting extracellular signal-regulated kinase 1/2 phosphorylation. YD-3 could potentially have value in elucidating the pathophysiology of thrombin-induced angiogenesis.
Smiles
O=C(OCC)C=1C=CC(=CC1)C2=NN(C=3C=CC=CC23)CC=4C=CC=CC4
Molecular Formula
C23H20N2O2
Molecular Weight
356.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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