YD-3

• CAS Number :

  170632-41-4

• Target :

  Thrombin

• Related Pathways :

  Proteases/Proteasome

• Bioactivity :

  YD-3 is a PAR4 antagonist that significantly inhibits thrombin-induced platelet aggregation in rabbits (IC (50) =28.3 microM) . In addition, YD-3 suppresses thrombin-induced proliferation of vascular smooth muscle cells (VSMCs) and reduces neointimal thickening after balloon injury. Through Ras- and ERK1/2-mediated signaling pathways, YD-3 impedes thrombin-driven VSMC proliferation. When analyzed with Western blot, YD-3 primarily inhibits thrombin-induced expression of vascular endothelial growth factor receptor 2 (Flk-1) without affecting extracellular signal-regulated kinase 1/2 phosphorylation. YD-3 could potentially have value in elucidating the pathophysiology of thrombin-induced angiogenesis.

• Smiles :

  O=C(OCC)C=1C=CC(=CC1)C2=NN(C=3C=CC=CC23)CC=4C=CC=CC4

• Molecular Formula :

  C23H20N2O2

• Molecular Weight :

  356.42

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C