PfCLK3-IN-1

CAT: 0931-T201861-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T201861-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

ABC Transporter, Endogenous Metabolite, Parasite

Related Pathways

Microbiology/Virology, Membrane transporter/Ion channel, Metabolism

Bioactivity

PfCLK3-IN-1 (Compound 4) serves as a covalent inhibitor of the malaria parasite CLK3 (Pf CLK3) under alkaline conditions, with a pEC50 of 7.1. It inhibits the maturation of gametocytes during the sexual stage of the parasite, thereby hindering transmission. Additionally, PfCLK3-IN-1 effectively suppresses the Dd2-B2 clone of the malaria parasite, exhibiting an IC50 of 239.5 nM.

Smiles

OC(C(C=C1)=CC=C1C2=C(C=C(C3=CC(CN4CCN(C(CCl)=O)CC4)=CC=C3OC)N5)C5=NC=C2)=O

Molecular Formula

C28H27ClN4O4

Molecular Weight

518.99

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-159963	PfCLK3-IN-1
OF59775-01	1,1,1,1,1-Kestoheptaose
N2864-5.1	1,1,1,1-Kestohexaose
112040	1,1,1,1-Kestohexose
410417-01	1,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride
IFA69273-01	1-Iodobicyclo[1.1.1]pentane
OR312388	1-Phenylbicyclo[1.1.1]pentane
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PfCLK3-IN-1

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