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4-Chloropyridine

CAT: 0931-T201645-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201645-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
626-61-9
Target
Parasite, Others
Related Pathways
Others, Microbiology/Virology
Bioactivity
4-Chloropyridine acts as an inhibitor of Nicotinamide N-methyltransferase (NNMT) . Serving as a substrate for NNMT, this compound enhances the electrophilicity at the C4 position through methylation of the pyridine nitrogen. This modification facilitates an aromatic nucleophilic substitution reaction with the non-catalytic cysteine (C159) in NNMT, ultimately leading to suicidal activity inhibition of the enzyme. 4-Chloropyridine is a promising candidate for the development of activity-based probes targeting NNMT functions.
Smiles
ClC=1C=CN=CC1
Molecular Formula
C5H4ClN
Molecular Weight
113.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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