CL-13

CAT: 0931-T201512-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T201512-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Beta Amyloid, Cholinesterase (ChE)

Related Pathways

Neuroscience

Bioactivity

CL-13 is an inhibitor of butyrylcholinesterase (BChE), exhibiting an IC50 of 1.15 μM and a selectivity index (SI) of 9.2 for acetylcholinesterase. It demonstrates antioxidative activity in SH-SY5Y cells with a DPPHEC50 of 47.01 μM and has the capacity to chelate metals involved in Aβ aggregation and/or oxidative stress, showing no neurotoxicity at concentrations up to 50 μM. CL-13 can also reverse scopolamine-induced cognitive impairments without affecting motor abilities in mice.

Smiles

CC(C)(C)C1=CC(/C=N/NC(NC2=C3C(C=CC=C3)=NC4=C2C=CC=C4)=S)=CC(C(C)(C)C)=C1O

Molecular Formula

C29H32N4OS

Molecular Weight

484.66

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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CL-13

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