PAK4-IN-5

• Target:

  PAK|||Reactive Oxygen Species|||Apoptosis

• Related Pathways:

  Immunology/Inflammation|||NF-?B|||Cytoskeletal Signaling|||Metabolism|||Apoptosis

• Bioactivity:

  PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0/G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg/kg (oral) .

• Smiles:

  O=C (NC1=CC=CC (Cl) =C1) C (C=C2) =CC=C2C (N3) =NC (C3=C4) =CC=C4C5=CC=C (N6CCN (C) CC6) C=C5

• Molecular Formula:

  C31H28ClN5O

• Molecular Weight:

  522.04

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C