PAK4-IN-5

• Target :

  PAK|||Reactive Oxygen Species|||Apoptosis

• Related Pathways :

  Immunology/Inflammation|||NF-?B|||Cytoskeletal Signaling|||Metabolism|||Apoptosis

• Bioactivity :

  PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0/G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg/kg (oral) .

• Smiles :

  O=C(NC1=CC=CC(Cl)=C1)C(C=C2)=CC=C2C(N3)=NC(C3=C4)=CC=C4C5=CC=C(N6CCN(C)CC6)C=C5

• Molecular Formula :

  C31H28ClN5O

• Molecular Weight :

  522.04

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C