PAK4-IN-5

CAT: 0931-MF-0110691-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0110691-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PAK|||Reactive Oxygen Species|||Apoptosis
Related Pathways
Immunology/Inflammation|||NF-?B|||Cytoskeletal Signaling|||Metabolism|||Apoptosis
Bioactivity
PAK4-IN-5 (Compound 12i) is a potent inhibitor of PAK4 (IC50: PAK4 at 7.68 nM, PAK1 at 1872.01 nM) that forms stable interactions with the PAK4 enzyme. This compound effectively inhibits the proliferation and migration potential of MDA-MB-231 cells by hindering the phosphorylation of PAK4 and LIMK1. Additionally, PAK4-IN-5 arrests the cell cycle in the G0/G1 phase, induces apoptosis, and prompts the production of reactive oxygen species. The LD50 in mice is greater than 500 mg/kg (oral) .
Smiles
O=C(NC1=CC=CC(Cl)=C1)C(C=C2)=CC=C2C(N3)=NC(C3=C4)=CC=C4C5=CC=C(N6CCN(C)CC6)C=C5
Molecular Formula
C31H28ClN5O
Molecular Weight
522.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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