BAY 593

• CAS Number :

  2413020-57-0

• Target :

  YAP

• Related Pathways :

  Stem Cells

• Bioactivity :

  BAY 593 functions as an inhibitor of geranylgeranyltransferase-I (GGTase-I), effectively preventing the activation of Rho-GTPases and consequently inactivating YAP1/TAZ signaling pathways. It has been shown to inhibit tumor growth dose-dependently in xenograft mouse models, exhibiting IC50 values of 38.4 nM in MT-1080 cells and 564 nM in MDA-MB-231 cells, as well as in PXF 541 xenografts.

• Smiles :

  O(C)C1=C([C@H]2C3(CCN(C([C@](C(F)(F)F)(OC)C4=CC=CC=C4)=O)CC3)CCNC2)C=CC=C1.Cl

• Molecular Formula :

  C26H32ClF3N2O3

• Molecular Weight :

  512.99

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C