Products for Research Use Only
RegisterLogin

SZU-B6

CAT: 0931-T200927-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T200927-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
3059333-98-8
Target
Sirtuin, PROTACs, Apoptosis
Related Pathways
PROTAC, DNA Damage/DNA Repair, Apoptosis, Chromatin/Epigenetic
Bioactivity
SZU-B6, a PROTAC degrader, targets and degrades SIRT6 with DC50 values of 45 nM in SK-HEP-1 cells and 154 nM in Huh-7 cells. It inhibits the proliferation of SK-HEP-1 cells with an IC50 of 1.51 μM and suppresses colony formation in both SK-HEP-1 and Huh-7 cell lines. Additionally, SZU-B6 induces apoptosis in SK-HEP-1 cells and causes cell cycle arrest at the G2/M phase. It demonstrates anti-tumor activity in murine models.
Smiles
O=C1C2=CC(F)=C(C=C2C(=O)N1C3C(=O)NC(=O)CC3)N4CCC(CN5CCN(C6=CC=C(C(N)=C6)N(=O)=O)CC5)CC4
Molecular Formula
C29H32FN7O6
Molecular Weight
593.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T3O2784-01Vitamin B6
TN9085-01Arylomycin B6
TN8035-01Procyanidin B6
T9901A-153-01Anti-CD47 Antibody (B6.H12)
TMAY-02421Anti-Serpin B6 Antibody (6G141)
TSW-00815-01Lipopolysaccharides, from E. coli O26:B6
TMPY-02242-01Serpin B6 Protein, Human, Recombinant (His)
TMPJ-00243-01Serpin B6 Protein, Human, Recombinant (E. coli, His)

Alternative Products

CatalogName
GTR19239870-01SZU-B6
MBS6005935-01PCDHGB6 (Protocadherin gamma-B6, PCDH-gamma-B6, PCDH-GAMMA-B6)
MBS3609121-01Vitamin B6
AP88189Serpin B6
GTR19236156-01Procyanidin B6
GTR19248450-01Arylomycin B6
KBH17464GENLISA Human Vitamin B6 (Vit B6) ELISA
RM-V307938-01Vitamin B6 Impurity 92 (Vitamin B6 Tetramer)
MBS1362833-01Recombinant Human herpesvirus 6B Protein B6 (B6)

Popular Products