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A-889425

CAT: 0931-T200890-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200890-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1072921-02-8
Target
TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
A-889425 is a selectively active oral TRPV1 receptor antagonist with IC50 values of 335 nM (rat) and 34 nM (human) . This compound effectively penetrates the central nervous system, reducing mechanical allodynia and the response of spinal neurons to mechanical stimuli in rat paws following inflammation induced by Complete Freund's Adjuvant.
Smiles
O=C(NC1=CC=C(C=C1)S(=O)(=O)C(F)(F)F)C2=CCN(C3=NC=CC=C3C)CC2
Molecular Formula
C19H18F3N3O3S
Molecular Weight
425.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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