SLC7A11-IN-2

CAT: 0931-T200659-01Size: 100 mgDry Ice: NoHazardous: No

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CAT#:0931-T200659-01Size:100 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

14668-59-8

Target

Others, Reactive Oxygen Species

Related Pathways

Immunology/Inflammation, Metabolism, Others, NF-κB

Bioactivity

SLC7A11-IN-2 (Compound 1) is an inhibitor of SLC7A11/xCT. It disrupts the oxidative balance in HeLa cells by decreasing intracellular glutathione levels and increasing oxidative stress, thereby inducing cell death with an IC50 of 10.23 μM. Molecular dynamics simulations have demonstrated that SLC7A11-IN-2 exhibits a stronger binding affinity to SLC7A11 compared to Erastin. This compound is useful for research in the field of cervical cancer.

Smiles

O=C(NNC=1C=CC=CC1)C(C(=O)NNC=2C=CC=CC2)CC(O)CC

Molecular Formula

C19H24N4O3

Molecular Weight

356.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19238706-01	SLC7A11-IN-2
334700-01	SLC7A11
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SLC7A11-IN-2

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