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W4275

CAT: 0931-T200598-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200598-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3051650-00-8
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
W4275 (Compound 42) is a selective NSD2 inhibitor with oral activity and an IC50 of 17 nM. It exhibits antiproliferative activity, with an IC50 of 230 nM against RS411 cells, and significantly inhibits tumor growth in an RS411 tumor xenograft model. Pharmacokinetic analysis in mice shows that W4275 has a favorable oral bioavailability (F is 27.34%) . W4275 holds potential for use in cancer research.
Smiles
N#CC=1N=C2C=C(OCCCN3CCOCC3)C(OC)=CC2=C(N1)NC4CCN(CC4)C(C)C
Molecular Formula
C25H36N6O3
Molecular Weight
468.59
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-168035-01W4275

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