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WB436B

CAT: 0931-T200318-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200318-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2248552-84-1
Target
Apoptosis, STAT
Related Pathways
JAK/STAT signaling, Apoptosis, Stem Cells
Bioactivity
WB436B, a highly selective STAT3 inhibitor, effectively targets and inhibits STAT3-Tyr705 phosphorylation along with the expression of STAT3 target genes. It exhibits cytotoxic effects on pancreatic cancer cells by inducing apoptosis. Furthermore, WB436B suppresses tumor growth and metastasis in pancreatic cancer mouse models, thereby prolonging the survival of tumor-bearing mice.
Smiles
N#CC1=C(SC2=C1CCN(C(=O)NC=3C=CC=CC3OC)C2)NC(=O)C=4C=NN(C4)C
Molecular Formula
C21H20N6O3S
Molecular Weight
436.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19239047-01WB436B

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