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LX1

CAT: 0931-T200147-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T200147-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2647877-84-5
Target
Androgen Receptor, Reductase
Related Pathways
Metabolism, Endocrinology/Hormones
Bioactivity
LX1, an anti-prostate cancer compound, specifically targets the androgen receptor (AR), AR variants, and the steroidogenic enzyme AKR1C3. It inhibits AKR1C3's enzymatic function, decreases the conversion of androstenedione to testosterone, and reduces the expression of both AR and AR-V7, subsequently downregulating their target genes. Additionally, LX1 is effective in overcoming tumor cell resistance to Enzalutamide, and when combined with Enzalutamide, it further suppresses tumor growth.
Smiles
O=C(NC=1C=C(C=C(C1)C(F)(F)F)C(F)(F)F)C2=CC(=CC=C2O)CC=3C=CC=CC3
Molecular Formula
C22H15F6NO2
Molecular Weight
439.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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