GTSE1-IN-1

CAT: 0931-T200127-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T200127-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3002034-34-3

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/Checkpoint, DNA Damage/DNA Repair

Bioactivity

GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.

Smiles

FC1=CN=C(N=C1NC2=CC=C(N)C=C2)NC3=CC=C(C=C3)N4CCN(C)CC4

Molecular Formula

C21H24FN7

Molecular Weight

393.46

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19239238-01	GTSE1-IN-1
523699-01	GTSE1
70R-5612	GTSE1 antibody
530811-01	GTSE1 discontinued
TS402829P5	GTSE1 CytoSection

GTSE1-IN-1

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