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AD1058

CAT: 0931-T200105-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T200105-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2907782-78-7
Target
Src, Apoptosis, AMPK, ATM/ATR, mTOR
Related Pathways
Apoptosis, Tyrosine Kinase/Adaptors, Angiogenesis, PI3K/Akt/mTOR signaling, Chromatin/Epigenetic, DNA Damage/DNA Repair
Purity
0.9824
Bioactivity
AD1058 is a potent and selective ATR inhibitor (IC50 = 1.6 nM) that crosses the blood-brain barrier with significant in vivo anticancer activity. It is commonly used in the study of brain metastasis and CNS metastasis by inhibiting cell proliferation, disrupting the cell cycle and inducing apoptosis.
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C[C@H]1N(C2=C3C(=NC(=N2)C4=C5C(=NC=C4)NC=C5)N(S(C)(=O)=O)C=C3)CCOC1
Molecular Formula
C19H20N6O3S
Molecular Weight
412.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
BUP20642AD1058

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