Tetrahydrouridine

CAT: 0931-T17059-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T17059-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

18771-50-1

Target

Others, DNA/RNA Synthesis, DNA Methyltransferase

Related Pathways

Others, Chromatin/Epigenetic, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

Bioactivity

Tetrahydrouridine (NSC-112907; THU) is a multidrug resistance modulator. It can be used in cancer treatment to make tumor cells more sensitive to radiation therapy. THU is a competitive cytidine deaminase (CDA) inhibitor that inhibits deamination in the catabolism of cytotoxic deoxycytidine analogs such as ara-C and Gemcitabine.

Smiles

O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(O)CC2

Molecular Formula

C9H16N2O6

Molecular Weight

248.23

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

Tetrahydrouridine

Tetrahydrouridine has been used in trials studying the treatment of Neoplasms, Lung Neoplasms, Breast Neoplasms, Sickle Cell Disease, and Head and Neck Cancer, among others.

CAS Number	18771-50-1
PubChem CID	29243
IUPAC Name	1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one
Molecular Formula	C9H16N2O6
Molecular Weight	248.23
XLogP	-2.4
Topological Polar Surface Area	122
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Heavy Atom Count	17
Formal Charge	0
Complexity	301

SMILES

C1CN(C(=O)NC1O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O

InChI

InChI=1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1

InChIKey

UCKYOOZPSJFJIZ-XVKVHKPRSA-N

Chemical Structure

2D Structure

CAS: 18771-50-1

CID: 29243

Formula: C9H16N2O6

MW: 248.23

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	248.23
XLogP3	-2.4
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Exact Mass	248.10083623
Monoisotopic Mass	248.10083623
Topological Polar Surface Area	122 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	301
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
MBS3842190-01	Tetrahydrouridine
HY-15345AS	Tetrahydrouridine-d3
A17215-5	Tetrahydrouridine 5mg
HY-15345AR	Tetrahydrouridine (Standard)
MBS5803279	Tetrahydrouridine dihydrate
A17215-1	Tetrahydrouridine 1mg
HY-15345-01	Tetrahydrouridine (dihydrate)
A17215-50	Tetrahydrouridine 50mg
MBS6026085-01	Tetrahydrouridine (THU)
A17215-10	Tetrahydrouridine 10mg

Tetrahydrouridine

Chemical Information

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